We woke up hours before dawn for #JPM18 biotech news. Here’s what you need to know

first_img Daily reporting and analysis The most comprehensive industry coverage from a powerhouse team of reporters Subscriber-only newsletters Daily newsletters to brief you on the most important industry news of the day STAT+ Conversations Weekly opportunities to engage with our reporters and leading industry experts in live video conversations Exclusive industry events Premium access to subscriber-only networking events around the country The best reporters in the industry The most trusted and well-connected newsroom in the health care industry And much more Exclusive interviews with industry leaders, profiles, and premium tools, like our CRISPR Trackr. Alex Hogan/STAT @adamfeuerstein Unlock this article — plus daily coverage and analysis of the biotech sector — by subscribing to STAT+. First 30 days free. GET STARTED Log In | Learn More What is it? About the Author Reprints [email protected] Adam Feuerstein What’s included?center_img GET STARTED We woke up hours before dawn for #JPM18 biotech news. Here’s what you need to know STAT+ is STAT’s premium subscription service for in-depth biotech, pharma, policy, and life science coverage and analysis. Our award-winning team covers news on Wall Street, policy developments in Washington, early science breakthroughs and clinical trial results, and health care disruption in Silicon Valley and beyond. SAN FRANCISCO — Investors attending the J.P. Morgan Healthcare conference here still work market hours, which means waking up well before dawn to catch all the biotech news hitting the wires at a reasonable hour on the East Coast.The news flow announced Sunday afternoon and Monday morning had mostly incremental updates and not necessarily positive ones, leaving the Nasdaq Biotech Index essentially flat. It’s also raining here. The JPM investor sentiment meter might have a hard time ticking past dreary. Senior Writer, Biotech Adam is STAT’s national biotech columnist, reporting on the intersection of biotech and Wall Street. He’s also a co-host of “The Readout LOUD” podcast. Biotech By Adam Feuerstein Jan. 8, 2018 Reprints Tags biotechnologyjpm18last_img read more

Stevens Sonora 29er Replaces 26 for USA, Xenon Road Bike Gets Matte Di2 Frame

first_imgStevens’ Sonora 29er carbon hardtail replaces the 26″ version that was recently brought to the US. It gets a tapered headtube, internal cable routing and a massive box section PF92 bottom bracket. Bike should retail for around $4,000 for this XTR build. Frame is $1,799.The Xenon road bike gets Di2 internal routing compatibility and a new matte finish. Frame is monocoque carbon and is their most popular road model. Click through for detail pics…last_img

$31m to advance [email protected]

first_imgSubscribe Get instant access to must-read content today!To access hundreds of features, subscribe today! At a time when the world is forced to go digital more than ever before just to stay connected, discover the in-depth content our subscribers receive every month by subscribing to gasworld.Don’t just stay connected, stay at the forefront – join gasworld and become a subscriber to access all of our must-read content online from just $270.last_img

GAME NOTES: UWF Christmas Classic

first_imgGAME NOTES: UWF Christmas Classic Share PENSACOLA, Fla. – The University of West Florida Argonauts will take on Saint Augustine’s College Friday and Virginia State on Saturday in the UWF Christmas Classic, both games are scheduled for 6 p.m. UWF now sits at 7-4 after taking down Shaw University and can match last season’s nine game win total with a pair of victories this weekend.2011-12 UWF Men’s Basketball Game Notes:- Games 12-13: St. Augustine’s and Va. State- Games 10-11: Ark.-Ft. Smith and Ark. Tech- Game 9: Shaw- Game 8: Ga. Southwestern- Games 6-7: Auburn Mont. and North Ga.- Game 5: Southeastern- Game 4: Ga. Southwestern- Game 3: Montevallo- Games 1 – 2: Lynn and BarryMOORE WINS SECOND GSC AWARDSenior Jamar Moore won his second GSC Player of the Week Award as he averaged a double-double behind 22.0 points and 12.5 rebounds, while also averaging 4.5 assists per game and shooting 53.1 percent from the field. Moore led UWF to an 88-70 victory over Arkansas-Fort Smith, netting 16 points and grabbing a game-high eight rebounds in 32 minutes. The Coolidge, GA native saved his best for last as the Argonauts nearly upset No. 24 Arkansas Tech, 89-85. Moore led all players with 28 points, 17 rebounds and seven assists in 36 minutes. He set a season-high for points in a game and a career-best effort on the boards.MATHIS GOES PERFECTUWF senior Marquis Mathis had a perfect night from the field during the Argo’s 88-70 win over Arkansas-Fort Smith. Mathis went 11-of-11 from the field, tying an NCAA record as well as a school record. Mathis is the first Argo to go perfect from the field after attempting more than nine shots.FIRST DECEMBER LOSSUWF’s loss to No. 24 Arkansas Tech was the first loss for the Argos in the month of December for both the men’s and women’s teams. The Argos were 2-0 until losing to the Wonder Boys this month while the women remain perfect at 3-0.GEARING UP FOR THE GSCThis weekend’s UWF Christmas Classic will wrap up the non-conference portion of the Argo’s schedule. Starting on Jan. 5, West Florida will kick off GSC play with Christian Brothers. UNO is the only remaining game on the schedule that will not count towards the Argo’s GSC record.LAST TIME VS. SAINT AUGUSTINE’SThe Argos defeated Saint Augustine’s, 86-77, on Dec. 30, 2005 in Pensacola, Fla. Maurice Thomas led the way with 24 points and 10 rebounds.LAST TIME VS. VIRGINIA STATEWest Florida took a 76-68 win over Virginia State two seasons ago on Dec. 30, 2009. Max Hoggard was good for 26 points while current Argo Peter Connole grabbed five rebounds and three assists.Print Friendly Versionlast_img read more

David Moyes hails Real Madrid as the best team he has ever faced

first_img He created the third goal for Karim Benzema but was unable to get on the score sheet and some sections of the home crowd were disappointed with his performance. CET The former Manchester United manager masterminded a win over Barcelona earlier this month, but he was unable to follow it up with another miracle in the Spanish capital. “We had that platform [through the early goal], but we couldn’t keep it. I know we lost but I really enjoyed my experience against one of the top sides in the world.” “On another day he will score because he is such a good player. He has nothing to worry about, he’s an exceptional player. Madrid didn’t need his goals today, but when they do need them he’ll be there.” Finally, Moyes revealed that Carlos Vela had to be taken off in the first half due to a “medial meniscus” problem, adding that a scan will determine how long the Mexican striker will be out for. David Moyes said the current crop of Real Madrid players may be the best side he has ever come up against after his Real Sociedad side were beaten 4-1 at the Santiago Bernabeu on Saturday afternoon. 01/02/2015 “The way [Madrid] played in the first half may be as good as I’ve come up against,” he said in his post match press conference. Sam Marsdencenter_img But while crediting Los Blancos, Moyes also admitted some frustration towards the way his side defended. “I was a little disappointed with my defenders,” he continued. “We needed to be more aware, but we were up against top quality players and that quality was able to shine through in the end. Moyes wasn’t the only British interest around the game, with Gareth Bale playing 90 minutes for Madrid. “Bale’s a top player,” Moyes continued. “You know the important thing when you have those players is that you encourage them. However, Moyes doesn’t think the Welshman should overly concerned with a bit of criticism. Upd. at 00:48 La Real had taken a shock second minute lead, although it didn’t last for long as James Rodriguez headed in Marcelo’s cross almost instantly to level the scores. “They forced us wide, they were difficult to get close to and they made it really hard for us.”last_img read more

Active citizenship in South Africa at a healthy level

first_imgSouth Africans, on the whole, have a high level of social cohesion and good active citizenship. To boost levels further, young people and marginalised groups in particular need to be targeted, according to Brand South Africa’s Domestic Perceptions Survey. Matjididi Mokono (centre) is an example of active citizenship in motion. She opened up an orphan centre in 2002 to feed and educate children in the village of GaMagoa in Limpopo. Active citizenship in South Africa has risen in recent years. (Images: Shamin Chibba) Shamin ChibbaMore than 10 years ago, when Matjididi Mokono was a primary school teacher, she looked at her community in GaMagoa, Limpopo, and saw its children struggling to live. They were not being fed well enough, many lived with their grandparents, and they were trying to get by in an environment rife with crime, alcoholism and drug abuse.Mokono did something about it. She left her post as a teacher and started Mponogele Le Iterele Orphan Centre under a tree. The initiative was meant to feed and educate the local children. “I wanted to help the children and support their family members who feel overloaded too,” she said.So successful was the project, Mokono started receiving support from the likes of Eskom, Brand South Africa and even overseas funders. Today, the centre has moved from the tree to a property with a small hall, a kitchen and even a computer room.It is people like Mokono who are pushing up South Africa’s score on the active citizenship index, which currently sits at 68%.The index forms part of Brand South Africa’s Domestic Perceptions Survey, which measures both active citizenship and social cohesion. It also contributes to developing an understanding of how South Africans perceive the nation brand based on national pride, attitudes, values and beliefs. On the whole, the survey found South Africans to be positive and optimistic about the future of the country.“South Africans tend to speak badly about themselves,” said Brand South Africa’s research manager Judy Smith-Höhn. “There’s a general tendency to say things are terrible. But what we are able to do is tell the positive story. We’re not looking to cover up challenges.”Active citizenshipWhile the active citizenship score was considered good, Smith-Höhn said there was still a lot of work to be done to take it to a level that was considered strong.The score implies that more than half of South Africans participate actively in their respective communities. But the study sample showed that 29% were involved community members who were always willing to contribute to their communities. The bulk of the sample, 53%, would like to be involved members but did not always have the time or money to do so.Level of involvement by percentage. (Images: Brand South Africa) The above graph shows the extent of the respondents’ involvement in their communities. (Images: Brand South Africa)Social cohesionSouth Africans were starting to feel they belonged to the country and that they wanted to be here, said Smith-Höhn.The country’s social cohesion score was 73 out of 100, which was a healthy sign, she said. “We have a very high social cohesion index, which is surprising if you think of where we come from as a country.”Based on questions posed to all respondents, research findings revealed that almost half of South African citizens had a strong feeling of cohesion (45%) while 21% had a good sense of cohesion.A breakdown of the social cohesion index. (Images: Brand South Africa)Social cohesion in the Brand South Africa context refers to the degree to which people are integrated in society. Furthermore, it looks at how society’s solidarity finds expression among individuals and communities.In a country with diverse histories, cultures and religions, people feel their living environments are improving. There are fewer feelings of inequality, exclusion and disparity. More than half the respondents felt they were always part of the bigger South African community, and only 10% felt they were always excluded. The remaining 36% said they were sometimes excluded.The above graph indicates the respondents’ feeling of inclusion as a South African citizen. They had to pick one of the above three statements that best described their feelings as an individual living in South Africa. (Images: Brand South Africa)Despite the good vibes South Africans were emanating, the Domestic Perceptions Survey noted that lower income earners were showing some frustration. “The slight dissatisfaction among South Africans around the feelings of inclusion are, in fact, the reason why social cohesion is ‘good’ and not ‘strong.’”According to Brand South Africa, social cohesion improves a country’s economic performance because a more equal society and environment correlate with positive outcomes such as good health, child development and labour market adjustments.The above graph broke down the feelings of inclusion by income levels. A high level of respondents (57%) felt they were part of the bigger South African community. (Images: Brand South Africa)Social cohesion forms a large part of the social sustainability element in the World Economic Forum’s Global Competitiveness Index. Even Mo Ibrahim, the billionaire Sudanese-British mobile communications mogul, emphasised the importance of social cohesion at the 11th Nelson Mandela Annual Lecture in 2013.The National Development Plan (NDP) has made social cohesion one of its priorities for the 2014-2019 electoral mandate. According to the NDP, its objectives are to reduce inequality of opportunity and enable the sharing of common space.Active citizenry linked to unityThe Domestic Perceptions Survey linked active citizenship and social cohesion. It found that an active citizenry was a key component of a more socially cohesive society. “Citizens need to help shape the development process and hold the government to account for the quality of services it delivers.”The report offered two recommendations: promote youth participation as a way to enhance active citizenship and promote inclusiveness among marginalised groups to enhance feelings of cohesiveness.last_img read more

Ask.com: What differentiates it from Google?

first_imgWhy Tech Companies Need Simpler Terms of Servic… Related Posts Other Features & ConclusionAsk.com also says it does social search, but rather than rely on user tagging – whichthey say is only popular in niche tech circles (e.g. del.icio.us and Flickr) – Ask.comlets its algorithm do the work. It does this by breaking terms down into groups andpresenting the results to the user. If you do asearch on gardening for example, you’ll see how it is broken down into multiplecategories.Ask.com also has the usual search portal (circa 2006) features – mobile, maps, news,blogs, binoculars (page preview), etc. There are subtle differences in all of thosefeatures when compared to Google, Yahoo and MSN. But ultimately I have to ask (pardon thepun): is Ask.com ‘next generation’ enough to challenge the big 3 plus AOL?I do like the concept of ExpertRank and their willingness to get as much useful infoon the first page of search results as possible. It seems like an innovative approach andcertainly differentiates Ask from Google.But when it comes down to it, the results I see aren’t sufficiently differentto make me want to change. I suspect a lot of Google’s 50%+ market share of users feelsthe same. Ask.com is still a successful business though, even if they don’t manage tomake great inroads into the market. I’m sure Ask is not crying into its milk about being5th. I was told that currently over 20% of Ask’s entire search terms – and hundreds ofcategories – have a Smart Answer.Comparison of Ask with GoogleIf you compare Ask.com to Google, there are immediately some noticeable differences.An obvious one is that Ask.com puts its advertisements within the main content pane,instead of in a separate right-hand pane like Google does. So when you do a generalsearch in Ask, the right-hand pane is sometimes occupied by advanced search options. AlsoAsk often has their ‘smart answers’ (see above) at the top of the main pane. The effectof all this is to give the user more immediately useful information – and drill downoptions – on the first page of results. This is what Jim Lanzone meant at Web 2.0 Summitwhen hesaid that “Ask.com enables users to do more, faster.”Below are a couple of screenshots, showing a search on “new zealand” in Ask, followedby the same query in Google: A Web Developer’s New Best Friend is the AI Wai… During the Web 2.0 Summit, I got a chanceto sit down with the team at Ask.com and find out moreabout their search engine. This was straight after a Summit session entitled ‘DisruptionOpportunity: Beating Google at Their Own Game’ – in which Ask CEO Jim Lanzone and SeniorVP of the Online Services Group at Microsoft (and ex-Ask CEO) Steve Berkowitz discussedwith John Battelle how they are competing with Google. R/WW’s coverage of thatsession ishere.Letting the stats do the talking…Whenever I talk to or meet Ask.com people, I always get the feeling they are a littlepissed off at the lack of attention they get from blogs. To compensate, out come thestats to prove how big they are. For example, they often make a point of saying thatAsk.com is the 5th biggestsearch engine in theUS – behind Google, Yahoo, MSN and AOL. Also, Jim mentioned during the Summit sessionthat Ask is the 7thbiggest web property in the US – ahead of the likes of Amazon, NY Times andApple.So there’s no doubting that Ask.com is a significant player in the Web business – andI agree they don’t get their due for that. But what about the actual product – theAsk.com search engine. How does it stack up? I spoke to the team and took the searchengine for a test drive to find out…What really differentiates Ask from Google?I asked this of the Ask.com team, in our hallway meeting at the Summit. They told methat Ask’s technology “looks at the Web differently”. Whereas Google’s PageRank ranks itssearch results by popularity, Ask has something it calls “ExpertRank”. Essentially thisis an automated search algorithm (like Google has), but on top of that results areordered using topic communities and the editorial functions that create ‘Smart Answers’.While the ExpertRank formula is a secret sauce that Ask.com won’t divulge, they do saythat the top results in searches are determined by expertise – and not popularity. As itstates on their helppages:“Identifying topics (also known as “clusters”), the experts on those topics, and thepopularity of millions of pages amongst those experts — at the exact moment your searchquery is conducted — requires many additional calculations that other search engines donot perform.”Smart AnswersI was curious to know how ‘smart answers’ are determined. For a start, they don’t popup on every search result – for example a search for “richard macmanus” displays myprimary RSS feed at the top of the page, instead of a smart answer. The Ask team told methat smart answers are editorially done – and is a reminder of their natural languagepast. If you recall, Ask Jeeves (as it used to be known before the butler was fired, er Imean de-commissioned) started out as a search engine where you could ask a naturallanguage question – e.g. “what the heck is web 2.0?” – and get back a good answer. SmartAnswers is an extension of that philosophy of providing a natural language answer to auser’s search query. It does this by a combination of automated data mining and humaneditorial. But the human editors don’t physically write the answers, I was told – ratherthey act as aggregators and filters.center_img richard macmanus Top Reasons to Go With Managed WordPress Hosting Tags:#search#web 8 Best WordPress Hosting Solutions on the Marketlast_img read more

Lucescu: ‘Costa has Mbappe quality’

first_img Watch Serie A live in the UK on Premier Sports for just £11.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://subscribe.premiersports.tv/ Juventus winger Douglas Costa “has no reason to envy Kylian Mbappe”, according to former Shakhtar Donetsk boss Mircea Lucescu. Costa scored a stoppage-time winner for Juve against Lokomotiv Moscow in style midweek, dribbling past three defenders, completing a give-and-go and beating another two men before nutmegging the goalkeeper. After watching that goal, Lucescu likened the 29-year-old in terms of ability to Mbappe, who is considered the world’s best player under the age of 21. “Douglas Costa, in terms of quality, has no reason to envy Mbappe at PSG,” he told Tuttosport. “The other day he scored a beautiful goal in the Champions League, but he’s got the quality to score goals like that every game. “Trust me, I know,” added the 74-year-old, who brought the Brazilian to Europe during his successful tenure at Shakhtar. Costa has netted just eight times in three seasons with the Bianconeri, although he did provide 12 assists in Serie A during his first campaign. “He’s a very generous player, he prefers to make an assist than score himself.”last_img read more

After Lok Sabha nod, GST Bill up for Rajya Sabha test

first_imgFinance minister Arun JaitleyThe government on Wednesday passed the key economic reform Goods and Services Tax (GST) regime in the Lok Sabha amid a walkout by the Congress. However, the Modi government will face the Opposition hurdle when the legislation will be taken up in Rajya Sabha on Thursday.The Bill was passed in the Lower House where the government has a brute majority, despite the Congress staying away from voting and the AIADMK voting against the legislation.But the government managers are keeping their fingers crossed knowing well that the Opposition might force it to refer the Bill to Select Committee for further consultations in the Upper House.However, the Opposition Trinamool Congress and BJD are supporting the Bill. Parliamentary Affairs Minister M. Venkaiah Naidu and Finance Minister Arun Jaitley are talking to the Opposition parties to enlist their support for the legislation which proposes a uniform tax regime across India. “We hope the Opposition parties would have the same view in the Rajya Sabha. We are talking to the parties,” Naidu said.Congress member M. Veerappa Moily said the party supports the Bill in principle as it was pushed by the previous UPA also. However, Congress wants that some new clauses added by the government should be consulted in a Select Committee of the upper house.The government managed the mandated two-thirds majority to pass the constitutional amendment Bill in the lower house. But carrying it forward in the upper house would be a big challenge where the NDA lacks strength.advertisementThe Constitution Amendment Bill to implement GST, originally mooted by the UPA, was passed by 352 votes against 37 after the government rejected the Opposition demand of referring it to a Standing Committee.Noting the Bill would make India a single market, Jaitley rejected the Opposition demand for referring the Bill to the Standing Committee, saying the panel has already examined various provisions of the new legislation and several of its suggestions have been incorporated. “GST is not a dancing instrument that it will jump from Standing Committee to Standing Committee.”Jaitley said he would compensate states for any revenue loss. “I straightaway concede that 27 per cent (revenue neutral rate) would be very high. We have decided to keep petroleum out, and every state finance minister is not interested in imposing higher taxes on its own people, and neither the Central government,” he said.Jaitley said the proposal to reform the indirect taxes has been pending for the last 12 years and his predecessor P. Chidambaram of the Congress had also mooted it during the UPA rule.Meanwhile, Prime Minister Narendra Modi was not present in the Lok Sabha when it passed the GST bill. Modi’s absence in the Lower House was conspicuous as he has been particular about MPs’ attendance and has often made them explain their absence from the House.last_img read more

The English Premier League Starts Today Heres One Reason To Watch

Beautiful, ain’t it? Americans’ interest in soccer is about three times higher during the World Cup than it usually is, judging by how often they search for the sport on Google. But that isn’t true for other countries. In England, where the English Premier League will kick off its season on Saturday, club play is followed almost as enthusiastically as international competition. The same is true in Spain, Italy, Brazil and Mexico.What accounts for the international appeal of soccer? One factor may be the comparative simplicity of its rulebook. Product designers have long appreciated the value of simplicity, which offers a gentler learning curve and fewer opportunities for mistranslation.I downloaded the FIFA Laws of the Game along with the rulebooks for the NFL, NBA, NHL and Major League Baseball. Then I counted the number of words in each one, excluding indices. This is a simple proxy for the complexity of each sport.Soccer is doing more with less; FIFA’s rulebook has just over 20,000 words. By contrast, the NBA’s has 30,000, MLB’s is close to 50,000, the NHL’s is nearly 60,000 and the NFL’s is 70,000.The correlation between the simplicity of a sport’s rulebook and its global popularity is almost one to one. Soccer, with its simple rulebook, is followed in almost every country. Basketball increasingly is, too. The more complex sports have less global appeal. Baseball is popular in the Americas and Japan but not yet elsewhere. Hockey fans are almost exclusively concentrated in the U.S., Canada, Northern Europe and Russia. American football has few fans outside America itself.Philosophers have also long recognized a connection between simplicity and beauty (indeed, long before soccer came to be known as “The Beautiful Game,” it was known as “The Simplest Game” instead). This June, when I attended a couple of World Cup matches at the Maracanã, in Rio de Janeiro, I was struck by how rich the experience was with so few frills. There was no 60-yard-long Jumbotron — there were hardly any scoreboards. There weren’t many words spoken, on or off the pitch.Soccer can get away with this minimalist presentation because of the simplicity of its rulebook; you don’t need Ed Hochuli to come out and explain the difference between offsides and encroachment and a neutral zone infraction.Instead, when Chile scored against Spain in their Group B match, it sounded something like this (sorry about my shaky camera work): read more