Pharmalot Hello, everyone, and how are you today? Cold winds are whipping about the Pharmalot campus, where things have settled down now that the short person is hovering over the laptop once again and the official mascot has assumed his formal snoozing position. As for us, we are dutifully concocting a few needed cups of stimulation as we dig in for another busy day. No doubt, you can relate. So time to get cracking. As always, we have assembled some items of interest. So hoist your own cup to a successful day, and drop us a line when something interesting arises. …At least one Democratic lawmaker is openly pushing President Biden to include drug pricing reform in his next big legislative package, after rumors swirled on Capitol Hill that the forthcoming bill might not include such provisions, STAT reports. Rep. Peter Welch of Vermont planned to call the White House and is urging his colleagues to pressure the administration in a letter, too. His efforts suggest drug pricing advocates could face an uphill battle passing major drug pricing reform, even though Democrats control the House, Senate, and White House. Ed Silverman STAT+ is STAT’s premium subscription service for in-depth biotech, pharma, policy, and life science coverage and analysis. Our award-winning team covers news on Wall Street, policy developments in Washington, early science breakthroughs and clinical trial results, and health care disruption in Silicon Valley and beyond. Tags STAT+ Alex Hogan/STAT What is it? Log In | Learn More About the Author Reprints What’s included? Pharmalittle: Europe looks to sue AstraZeneca over Covid-19 vaccine shortfalls; FDA skewers Emergent vaccine facility Pharmalot Columnist, Senior Writer Ed covers the pharmaceutical industry. GET STARTED Unlock this article — plus daily coverage and analysis of the pharma industry — by subscribing to STAT+. First 30 days free. GET STARTED By Ed Silverman April 22, 2021 Reprints [email protected] Daily reporting and analysis The most comprehensive industry coverage from a powerhouse team of reporters Subscriber-only newsletters Daily newsletters to brief you on the most important industry news of the day STAT+ Conversations Weekly opportunities to engage with our reporters and leading industry experts in live video conversations Exclusive industry events Premium access to subscriber-only networking events around the country The best reporters in the industry The most trusted and well-connected newsroom in the health care industry And much more Exclusive interviews with industry leaders, profiles, and premium tools, like our CRISPR Trackr. @Pharmalot
KTRK(CLEVELAND, Texas) — Most toddlers are learning how to write or count. Thankfully, one Texas 3-year-old learned how to call 911.Dorothy Craig, of Cleveland, Texas, may very well have saved her mother’s life — or her siblings’ lives — on Wednesday when she collapsed and fell unconscious on the floor, according to Houston ABC station KTRK.That’s when Dorothy, not even old enough to go to school, sprang into action. The youngster picked up a phone and immediately called 911.In audio released of the 911 call, the dispatcher who picked up the phone is heard answering, “Liberty County 911.” Dorothy responded, “Mommy.”However, the little girl was unable to provide more information as the diligent dispatcher stuck with it to try to get more information from the girl.Eventually, when asked where her mother was, Dorothy was able to say “on the floor.”The Liberty County Sheriff’s Office was able to track the cellphone to find out generally where the call was coming from and found Dorothy’s mother, Miranda, after going door-to-door for a half hour.“I’m extremely proud of her. She’s such a smart little girl and she’s so charismatic,” Miranda said.Dorothy has two younger siblings, 2-year-old and 5 months old, who were also in the house unattended with their mother unconscious.Miranda suffers from narcolepsy, which causes people to suddenly fall asleep and can include hallucinations, loss of muscle control and muscle paralysis. She was treated by paramedics who responded to her home.Dorothy isn’t a one-hit wonder though. Miranda said she’s called 911 for her mother before.“When she was really little, I taught her how to call 911,” Miranda said. “And she’s done it for me twice now, and she’s my little … she’s my little hero.”Copyright © 2018, ABC Radio. All rights reserved.
“If Europe is serious about meeting the 2012 target,” says a Citibank analysis, “it has to encourage small cars, and discourage large ones.” It adds that this means expected growth in the SUV, sports cars and luxury car sectors will have to be “choked off”.The differing effects of legislation on different manufacturers will make it hard to find one common approach to reducing emissions.“The motor industry’s common position has broken down,” concludes the bank. “It’s likely to get ugly.”From Fiat to Volvo – how the car brands compare on C02Car brand (average CO2 emissions in 2005 (grams per kilometre)Fiat 139 European car industry organisation ACEA accused the Commission of hiding the true price of binding targets by leaving ECCP estimates out of its published assessment.But T&E, an environmental pressure group specialising in transport issues, says that the assessments were both based on outdated assumptions.The Commission says it is now working on a definitive impact assessment to accompany a proposal for legislation, not expected before the end of this year.EU industry analysts are also doing their best to work out what CO2 emission caps would mean for carmakers. An analysis by US bank Citibank says future legislation would give manufacturers producing small cars an advantage over those focusing on larger models. Fiat, Renault and PSA Peugeot Citroën in particular could see their profits rise, while BMW and DaimlerChrysler would start to lose money, at least in the short-term.Citibank singles out the Porsche Cayenne sports utility vehicle (SUV) as a model for which a CO2 cap in Europe would be “disastrous”. Opel/Vauxhall 156 Volkswagen 159 Toyota 163 Suzuki 165 Honda 166 Hyundai 170 Volvo 195 Source: T&E Germany has led countries arguing that binding targets would be too expensive for the European automotive industry, forcing investments and jobs out of the EU.A Commission impact assessment published this month said that hitting the 120g/km target could cost Europe up to €23 billion. An earlier draft impact assessment produced by the Commission’s European Climate Change Programme (ECCP) said the costs could run up to €60bn. Kia 170 Nissan 172 Audi 177 Mazda 177 Mercedes-Benz 185 BMW 192 Citroen 144 Renault 149 Seat 150 Ford 151 Peugeot 151 Skoda 152
All the nature studies conducted to date demonstrate that access to nature—both outdoors in natural settings and indoors through filmed footage, paintings, and photographs—can help people manage the stress and anxiety of modern life, especially during the COVID-19 pandemic. Read the whole story: Forbes More of our Members in the Media > A groundbreaking 2019 study in Scientific Reports found that spending a minimum of two hours a week in parks, woodlands, or beaches promotes physical and mental health and well-being and gives you a bigger perspective of your life circumstances. In the study, those who spent 120 minutes per week had better health and higher psychological well-being than the ones who didn’t spend any weekly time in nature or those who spent less than 120 minutes per week. The lead author, Mathew White, reported that it doesn’t matter how the 120 minutes are achieved. It can be done in one block or spread out over the entire week to get the benefit. It doesn’t seem to matter what activity you’re involved in, either, as long as you’re outdoors: sailing, biking, kayaking, walking or tennis. The types of news outlets, TV shows, movies, magazines, and newspapers we consume on a regular basis frame our perspective and impact our mental health and well-being. Long-standing research shows that chronic TV watchers and news followers have elevated fears because the events they observe start to seem as if they are happening outside their front door. And once we consume too much chronic, negative, and catastrophic information, we can’t put the toothpaste back in the tube. It stays in our minds, forming a template for how we think, feel, and respond to seismic events such as the COVID-19 pandemic. Fortunately, scientists have found an antidote: watching nature documentaries. … Scientists have amassed a body of research that shows exposure to natural green spaces such as parks, woodlands, mountains, and beaches has healing properties on your mental and physical health and well-being. It reduces anxiety and rumination and improves depression. Living in greener urban areas is linked to lower incidences of heart disease, obesity, diabetes, asthma, mental distress, and mortality rates. The decades-old Japanese practice of forest bathing or shinrin-yoku (which means “taking in the forest”) is believed to provide stress reduction, relaxation, and deeper insights into life. Scientists have discovered that forest bathing lowers cortisol and depression in adults and boosts the activity of killer cells that fight off infection and cancer. American journalist Richard Louv coined the term “nature-deficit disorder” to describe the human costs of living disproportionately indoors alienated from nature. Hence, the importance of connecting with nature and letting it transport and calm you—infuse you with mental clarity to replace the stress and recharge your batteries. Studies show that simply viewing an aspect of nature from an office window is restorative. Patients with a view of nature from their hospital window heal quicker than patients without a nature view. Studies also show that bringing nature indoors does the trick. If you live in an urban area, you can bring in potted green plants, fresh flowers, or a terrarium. And research shows that a tabletop trickling waterfall, an aquarium, fishbowl, or a CD with nature sounds contain stress-relieving and restorative properties. One of the most recent studies indicates that you can get nature’s benefits without even leaving your sofa, that simply watching a nature documentary reduces anxiety and raises your mood. Psychologist Dachner Keltner of the University of California, Berkley collaborated on a study with the BBC Worldwide. The study, known as The Real Happiness Project, was a joint effort between Keltner and the British Broadcast Company’s (BBC) in-house research team. The study included over 7,500 nationally represented participants from numerous countries who watched footage from Planet Earth 2. Scientists used cutting-edge facial mapping technology to measure emotional responses to the nature videos before and after participants viewed them. Results showed substantial decreases in stress, nervousness, anxiety, fear, stress, and fatigue and significant increases in relaxation, contentment, excitement, enthusiasm, joy, and awe. …
Who: Spencer Gomez, Chef de Cuisine at Southern Belle and Georgia BoyInstagram: @ChefSpencerGomezChef Gomez’s Guest-Worthy Recipe: Blue Crab Beau Monde dipWhy?“Blue Crab Beau Monde dip is the ideal hors d’oeuvre recipe for guests, whatever the season. It has been a staple at our family holidays for years. If crab is not available, the dip is great on its own or topped with chow-chow or kimchi. At Southern Belle, we serve it alongside local grit bread and Benne seed crackers, but it can be paired with anything: from Ruffles chips to sliced crudité! A celery root purée is often subbed for the mayonnaise to celebrate the celery flavors. For the always-busy home cook, crab dip can be made ahead, refrigerated, and served cold the next day.”Ingredients:For Dip16 oz cream cheese4 oz sour cream12 oz mayonnaise30 g scallions, sliced45 g celery, minced35 g shallot, minced7 g salt (or to taste)2 lemons’ zest & juice6 g vegetable bullion (beef is great also)12 g Spice Islands Beau Monde SeasoningFor Crab Salad Topping12 oz jumbo lump crab meatOlive oilLarge flake sea salt and black pepperOne large lemon zest and juice20 g chive, mincedDirections:For DipPaddle cream cheese in stand mixer.Add sour cream slowly until combined with the cream cheese.Add the remainder of dip ingredients until smooth.Transfer to a large bowl and chill.Crab Salad ToppingClean crab by picking out all shells.In a separate bowl, mix crab with olive oil, lemon juice, salt, pepper, and chives.Olive oil, salt, and pepper all added to taste.Spread out crab over the top of the previously finished dip.Chill and serve. Enjoy with crackers and bread, or as a spread on sandwiches or hors d’oeuvres. Share
By Bonny Burrows Premier Daniel Andrews has paid a visit to a Pakenham factory at the core of the Caulfield…[To read the rest of this story Subscribe or Login to the Gazette Access Pass] Thanks for reading the Pakenham Berwick Gazette. Subscribe or Login to read the rest of this content with the Gazette Digital Access Pass subscription.
Kinrade, 28, signed this fall with Medvescak of the Russian Kontinental Hockey League after three seasons with SC Bern of the Swiss Nationaliga. This will be Zagreb’s Bears’ first time taking part in this tournament.First round opponents include Swiss A-leaguers and last year’s Cup winners HC Geneve-Servette and Team Canada, a team comprised heavily of Canadian players who play in Europe.On the other side of the draw is the KHL’s Salavat Yulaev from Ufa, Finland’s Jokerit Helsinki and home team HC Davos.For Kinrade, this is the third time playing in the Spengler Cup — the first two for Team Canada.During his inaugural stint, Kinrade was part of the 2012 Spengler Cup Championship team.The former Kootenay International Junior Hockey League rearguard with the Nelson Leafs was one of the unsung defenders called upon by Hockey Canada due to a shortage of Canadian defencemen playing in Europe at that time.The team was bolstered by a huge NHL contingent of Jason Spezza, Patrice Bergeron, John Tavares, Tyler Seguin, Jonathan Bernier, Carlo Colaiacovo, Devan Dubnyk, Sam Gagner, Matt Duchene, Cam Barker and Captain Canada Ryan Smyth. The players were available due to the NHL lockout.Kinrade has enjoyed an illustrious career playing in Europe after spending two seasons in the American Hockey League with the Ottawa Senators farm team, Binghamton Sens, winning the Calder Cup in 2011.After graduating from college hockey at Michigan Tech, Kinrade played ten games with the Norfolk Admirals after signing a free agent contract and made his NHL debut on April 9, 2009 for Tampa against the Washington Capitals.The Spengler Cup is an international hockey tournament with a long tradition since 1923.Along with the Stanley Cup is the oldest championship in the world. The Cup is played for every year in Davos, Switzerland, in the time between Christmas and New Year. It is organized by A-leaguers Davos, and 2014 will see its 88th edition. Only teams that are invited can take part, and six teams fight for the trophy.Throughout all of the years of the Spengler Cup, which got its name from doctor Carl Spengler, numerous clubs from around the world have taken part, and the most wins go to the home team: Davos-15, followed b y Team Canada-12.Kinrade’s Zagreb’s Bears play the loser between HC Davos and Team Canada Saturday before meeting the winner Sunday.The top teams advance to the semi finals Tuesday with the final set New Years Eve.For more information check out the Spengler Cup website. KHL Medvescak Zagreb now meets HC Salavat Yulaev Ufa in quarterfinal action at the 2015 Spengler Cup in Davos, Switzlerland after dropping a 1-0 decision to the host club Sunday in round robin action.The winner of the Monday contest advances to the semi final round.Kinrade, KHL Medvescak Zagreb drop 3-1 decision to Team Canada at Spengler CupTeam Canada scored twice in the first period to defeat KHL Medvescak Zagreb 3-1 in Spengler Cup action Saturday in Davos, Switzerland.Nelson Minor Hockey grad Geoff Kinrade plays defence for KHL Medvescak Zagreb.Bud Holloway, Stefano Giliati and Alexandre Giroux scored to give Team Canada a 3-0 lead after two periods.Pascal Pelletier scored the lone goal for KHL Medvescak Zagreb.KHL Medvescak Zagreb plays host HC Davos Sunday in the final round robin game. HC Davos opened the tournament with a 2-1 win over Team Canada.Kinrade’s squad needs to win to advance to the playoff round in the tournament.Nelson’s Geoff Kinrade back at Spengler CupNelson Minor Hockey grad Geoff Kinrade is back playing at the Spengler Cup in Davos, Switzerland.However, the six-foot, 195-pound Nelson Leafs product is not playing on Team Canada this time around.The smooth skating defenceman is anchoring the blueline for Medvescak Zagreb’s Bears.
Donnacha O’Brien to be Crowned Champion Apprentice Rider Pat Smullen was first crowned Champion Jockey in 2000 and he heads the list for the ninth time this year. He is on-course to better his 2014 tally of 108 winners and will certainly count his Dubai Duty Free Irish Derby success on Harzand as the highlight of his domestic season. He also enjoyed notable success with Fascinating Rock, Shamreen and Zhukova. For the second successive year, Smullen looks set to beat Colin Keane into second place in the title race.Donnacha O’Brien (18) is another to enjoy a tremendous season and in just his third season riding has captured the Champion Apprentice title. Closing in on 50 winners, Donnacha is clear of Gary Halpin, Killian Leonard and his sister Ana in the table. The standout moment of his season was undoubtedly his first Group 1 success which came at the Curragh on Longines Irish Champions Weekend where he won the Moyglare Stud Stakes on Intricately, trained by his brother, Joseph. For good measure, the filly was bred by their mother, Annemarie. Donnacha also won a listed race and a Group 3 race on Order Of St George during the season. The 2016 Flat season draws to a close at Leopardstown on Saturday, October 29th, and the day will be marked by presentations to the champion owner, trainer, jockey and apprentice. Aidan O’Brien to Retain Champion Trainer Title The title of Champion Owner looks set to go right down to the wire with Mrs Sue Magnier holding the slenderest of leads over HH The Aga Khan. Part-owner of the brilliant Coolmore Fastnet Rock Matron Stakes winner Alice Springs and the Keeneland Phoenix Stakes winner Caravaggio, Mrs Magnier is bidding for her 14th owners’ title since 2000. HH The Aga Khan lies in a close second place in the current standings and he counts the Dubai Duty Free Irish Derby winner Harzand and Longines Irish Champions Weekend winner, Shamreen among his big winners.Aidan O’Brien is once again the Champion Flat Trainer. The fillies Minding and Found were his big prize-money winners during another tremendous season for Ballydoyle. O’Brien saddled Seventh Heaven to win the Darley Irish Oaks while he also enjoyed Group 1 success with the two-year-olds Churchill and Caravaggio. His other domestic Group 1 winner in 2016 was Alice Springs who won the Coolmore Fastnet Rock Matron Stakes at Leopardstown on Longines Irish Champions Weekend. Pat Smullen Set to Win Ninth Champion Jockey title print WhatsApp Facebook Twitter Email
A SECTION of Manchester United fans want Spurs to pip Liverpool to the title – despite the shock win likely to cost them Mauricio Pochettino.The Argentine Tottenham boss is a leading name in the race to take over at Old Trafford next season.2 Mauricio Pochettino is being lined up as Jose Mourinho’s replacement at Old TraffordCredit: Getty Images – GettyBut he’s also dangerously close to guiding his Harry Kane-led side to Premier League glory, thanks to Manchester City’s recent blip.Another trophy-less season would likely push Poch closer to the White Hart Lane exit, just a few months after their scheduled return after the new stadium is completed.But United fans are fearful another nearly season will let Jurgen Klopp and their bitter M62 rivals run away with the crown.On a Reddit forum, a group of impassioned supporters debated what it would mean to have Liverpool miss out on the title but themselves miss out on one of the Prem’s top bosses.2 The Tottenham manager is one of the huge favourites to take over the helm at Old Trafford next summerCredit: Reuterslatest football newsPicturedHARRY’S HEROES Kane says goodbye to Tottenham team-mates Vertonghen and VormLive Bloggunners newsArsenal transfer news LIVE – Latest updates from the EmiratesLive BlogUNITED LATESTMan Utd transfer news LIVE: All the gossip and updates from Old TraffordLive BlogTRANSFER NEWS LIVESalah admits he could LEAVE Liverpool, how Sancho will fit in Utd XILive Blogblues newsChelsea transfer news LIVE – Latest updates from Stamford BridgeRevealedFORTUNE TELLERIncredible Hawkeye blunder saved Villa’s lives – but Smith says it was karmaChampak256 wrote: “There’s two downsides to Spurs winning for me: it wasn’t us, and we won’t get Poch.“First one applies to anyone, and second one doesn’t compare to the downsides of each and every other team.Malpy 42 said: “If Tottenham win though. Poch won’t leave them for us. That’s my dilemma I think he’s one of the best men for long term at Old Trafford.”Toasterb wrote: “We don’t want the scum or City to win the league, and they want us to do well enough that we keep OGS on and they get to keep Poch.”Paul Pogba gives inspiring team-talk before Man Utd win over Huddersfield
The Ladyjacks had three golfers notch top-five showings, led by junior Sydney Reed’s runner-up finish with a 10-over 223 as she recorded a 2-over 73 over the final 18 holes. It was the second top-10 finish of Reed’s career and her first top-five showing as the 223 sets a new personal-low, besting the 226 she posted at the ULM Fred Marx Invitational in 2013. Three more Ladyjacks made appearances in the top-10, including sophomore Ann Holcomb who recorded an 18-over 231 competing as an individual. Holcomb tied for seventh overall, giving the sophomore her first career top-10 finish. She finished one stroke ahead of fellow sophomore Courtney Ford, who posted a 19-over 232 as an individual, placing eighth and notching her first career top-10 showing. Entering the day with a 23-shot lead on the host Cardinals, SFA showed it had no intention of relinquishing the lead, shooting a 12-over 296 in round three, which is tied for the second-lowest round in program history. The 296 matches SFA’s total at the 2013 Harold Funston Invitational and was just two shots off the pace of the program-low 294 carded at the Challenge at Onion Creek in 2013. The win gives SFA some momentum as it heads into the break, having wrapped up the fall portion of its 2014-15 schedule. The Ladyjacks finished in the top-10 in each of their five fall tournaments, highlighted by a second-place finish at the ASU Lady Red Wolf Classic before the championship performance in San Antonio. SFA notched eight top-10 individual showings, including Lautensack recording her first career tournament title. SAN ANTONIO, Texas – Stephen F. Austin capped its historic weekend in the Alamo City, shooting the lowest 54-hole total in program history en route to the program’s first-ever tournament title. The Ladyjacks closed out the Incarnate Word Wyndham Garden Riverwalk Fall Invitational with a 55-over 907, besting second-place Incarnate Word by 26 strokes to capture the team title. Holding a comfortable 23-stroke advantage heading into the final round, SFA extended that lead to 26 strokes to defeat host Incarnate Word (81-over 933). Murray State (140-over 992) finished third with Incarnate Word’s “B” team (171-over 1,023) and Ranger College (240-over 1,092) rounding out the top-five. SFA closed out the 54-hole event with a 55-over 907, which is the lowest 54-hole total in program history. It was four strokes lower than the previous mark of 911 at the Harold Funston Invitational in 2013 and 10 shots better than the 917 posted at the Challenge at Onion Creek, also in 2013. Sophomore Jessica White recorded the first top-10 showing of her career as well, shooting a 14-over 227 to finish third individually. White posted a 2-over 73 in the final round and joined Reed on the All-Tournament team. Freshman Erica Lautensack recored her second-straight top-five showing, finishing tied for fourth overall with a 15-over 228 as she now has two top-10 and four top-20 finishes through the first five tournaments of her career. Junior Mackenzie Steiner placed 10th overall, giving SFA six golfers among the top-10. Steiner carded a 20-over 233, highlighted by a 4-over 75 in round three, notching the first top-10 and second top-20 showing of her Ladyjack career. Freshman Jamee Jorgensen rounded out the Ladyjack competitors with a 13th-place showing, finishing with a 27-over 240 and a 4-over 75 in round three. She now has recorded a top-20 finish in back-to-back tournaments.