Chelsea Ladies sign England star Carney

first_imgChelsea Ladies have signed England international Karen Carney from Birmingham City Ladies.The 28-year-old midfielder, who has signed a two-year contract, has played 110 times for her country and was a key player for England at this year’s World Cup.Chelsea manager Emma Hayes has previously worked with Carney at Arsenal and the Chicago Red Stars.AdChoices广告“I am thrilled to have signed for Chelsea Ladies,” Carney said.“It is the right point in my career to begin a new challenge and having spoken to Emma we share the same ambitions and I firmly believe this is the place to achieve those goals.”Carney will be reunited with Chelsea’s former Arsenal players Katie Chapman, Gilly Flaherty and Gemma Davison.“I know her well having worked with her previously and she has a fantastic character both on and off the pitch,” said Hayes.“All our attacking players will benefit hugely from her vision and passing.” Follow West London Sport on TwitterFind us on Facebooklast_img read more

‘A new day for chemistry’: Molecular CT scan could dramatically speed drug discovery

first_img By Robert F. ServiceOct. 19, 2018 , 1:50 PM M. Martynowycz et al., ChemRxiv (2018), adapted by E. Petersen/Science (CC BY-NC-ND 4.0) ‘A new day for chemistry’: Molecular CT scan could dramatically speed drug discovery In chemistry, structure rules because it determines how a molecule behaves. But the two standard ways to map the structure of small organic molecules, such as pharmaceuticals, hormones, and vitamins, have drawbacks. This week, two research teams report they’ve adapted a third technique, commonly used to chart much larger proteins, to determine the precise shape of small organic molecules. The new technique works with vanishingly small samples, is blazing fast, and is surprisingly easy.“I am blown away by this,” says Carolyn Bertozzi, a chemist at Stanford University in Palo Alto, California. “The fact that you can get these structures from [a sample] a million times smaller than a speck of dust, that’s beautiful. It’s a new day for chemistry.”The gold standard for determining chemical structures has long been x-ray crystallography. A beam of x-rays is fired at a pure crystal containing millions of copies of a molecule lined up in a single orientation. By tracking how the x-rays bounce off atoms in the crystal, researchers can work out the position of every atom in the molecule. Crystallography can pinpoint atomic positions down to less than 0.1 nanometers, about the size of a sulfur atom. But the technique works best with fairly large crystals, which can be hard to make. “The real lag time is just getting a crystal,” says Brian Stoltz, an organic chemist at the California Institute of Technology (Caltech) in Pasadena. “That can take weeks to months to years.”Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)The second approach, known as nuclear magnetic resonance (NMR) spectroscopy, doesn’t require crystals. It infers structures by perturbing the magnetic behavior of atoms in molecules and then tracking their behavior, which changes depending on their atomic neighbors. But NMR also requires a fair amount of starting material. And it’s indirect, which can lead to mapping mistakes with larger druglike molecules.The new approach builds on a technique called electron diffraction, which sends an electron beam through a crystal and, as in x-ray crystallography, determines structure from diffraction patterns. It has been particularly useful in solving the structure of a class of proteins lodged in cell membranes. In this case, researchers first form tiny 2D sheetlike crystals of multiple copies of a protein wedged in a membrane.But in many cases, efforts to grow the protein crystals go awry. Instead of getting single-membrane sheets, researchers end up with numerous sheets stacked atop one another, which can’t be analyzed by conventional electron diffraction. And the crystals can be too small for x-ray diffraction. “We didn’t know what to do with all these crystals,” says Tamir Gonen, an electron crystallography expert at the University of California, Los Angeles (UCLA). So, his team varied the technique: Instead of firing their electron beam from one direction at a static crystal, they rotated the crystal and tracked how the diffraction pattern changed. Instead of a single image, they got what was more like molecular computerized tomography scan. That enabled them to get structures from crystals one-billionth the size of those needed for x-ray crystallography.Gonen says because his interest was in proteins, he never thought much about trying his technique on anything else. But earlier this year, Gonen moved from the Howard Hughes Medical Institute’s Janelia Research Campus in Ashburn, Virginia, to UCLA. There, he teamed up with colleagues, along with Stoltz at Caltech, who wanted to see whether the same approach would work not just with proteins, but with smaller organic molecules. The short answer is it did. On the chemistry preprint server ChemRxiv, the California team reported on Wednesday that when they tried the approach with numerous samples, it worked nearly every time, delivering a resolution on par with x-ray crystallography. The team could even get structures from mixtures of compounds and from materials that had never formally been crystallized and were just scraped off a chemistry purification column. These results all came after just a few minutes of sample preparation and data collection. What’s more, a collaboration of German and Swiss groups independently published similar results using essentially the same technique this week.“I’ve had dreams in my life where I’m looking through a microscope and I see a molecular model with balls and sticks,” Bertozzi says. “They basically find some microcrystalline schmutz on an EM [sample holder], take some data, and there are the balls and sticks I dreamed about. It’s unbelievable it works so well.”Because it does work so smoothly, the new technique could revolutionize fields both inside and outside of research, Bertozzi and others say. Tim Grüne, an electron diffraction expert at the Paul Scherrer Institute in Villigen, Switzerland, who led the European group, notes that pharmaceutical companies build massive collections of crystalline compounds, in which they hunt for potential new drugs. But only about one-quarter to one-third of the compounds form crystals big enough for x-ray crystallography. “This will remove a bottleneck and lead to an explosion of structures,” Grüne says. That could speed the search for promising drug leads in tiny samples of exotic plants and fungi. For crime labs, it could help them quickly identify the latest heroin derivatives hitting the streets. And it could even help Olympics officials clean up sports by making it easier to spot vanishingly small amounts of performance-enhancing drugs. All because structures rule—and are now easier than ever to decipher. The new technique managed to generate structures from a mixture that contained all four of these organic compounds.last_img read more

Mahesh Bhupathi and Sania Mirza reach French Open semis-finals

first_imgSania Mirza and Mahesh Bhupathi inched towards their second Grand Slam title together as they progressed to the mixed doubles semi-finals of the French Open after shocking second seeds Kveta Peschke and Mike Bryan, here on Monday.The seventh seed Indian pair breezed past the Czech-American pair 6-2, 6-3 in just under an hour in the quarter-finals of the clay court Major.The Indians saved all the four breakpoints they faced in the match and converted four of the five chances they got.Bhupathi and Mirza, the winners of the 2010 Australian Open, now await the winner of the other quarter-final match between the pairs of Galina Voskoboeva/Daniele Bracciali and Nuria Llagostera/Oliver Marach.Another Indian in the fray is Leander Paes, who along with Russian partner Elena Vesnina is set to take on top seeded Liezel Huber and Max Mirnyi in another last-eight stage contest.last_img read more

MS Dhoni centre of attraction in optional practice session at Eden Gardens

first_imgWith the three-match One-Day International (ODI) cricket series already in India’s pocket, the third rubber against England on Sunday has little importance. But not for former India captain Mahendra Singh Dhoni, who was seen in full tilt during the team’s optional training session at the Eden Gardens on Saturday. (Dhoni’s family, relatives expected to attend third ODI vs England)Only nine cricketers turned out on a sunny morning in Kolkata, with the likes of captain Virat Kohli and last match’s hero Yuvraj Singh opting out. Chief coach Anil Kumble was also absent from practice, with batting coach Sanjay Bangar present. (Dhawan battles thumb injury, not ruled out of third ODI)But what caught everyone’s eye was Dhoni who was seen hitting the nets — the first thig he did after entering the ground. (Mahendra Singh Dhoni first Indian to hit 200 ODI sixes)The 2011 World Cup winning skipper, who plundered the English attack in Cuttack with a calculative 134 off 122 balls, spent some time at the nets and was later seen assessing the pitch with keen interest. Dhoni also sat on his haunches, feeling the pitch with his hand. (Mahendra Singh Dhoni joins Tendulkar in elite list)With the ICC Champions Trophy being India’s next 50-over assignment and Dhoni now retired from Tests, the iconic wicket-keeeper doesn’t seem to take it easy by the look of things.Among those present in training were Shikhar Dhawan — battling a sore left thumb — Jasprit Bumrah, Kedar Jadhav, Ajinkya Rahane, Amit Mishra, Umesh Yadav, and Bhuvneshwar Kumar. Spin twins Ravichandran Ashwin and Ravindra Jadeja skipped training too.advertisementlast_img read more

Video: Here Is Connor Cook In His Full Oakland Raiders Uniform At The NFLPA Rookie Premiere

first_imgRaiders' Connor Cook in his uniform for the first time.Instagram/c_cook8After a fairly trying NFL Draft process, Michigan State quarterback Connor Cook landed with the Oakland Raiders in the fourth round. He will be behind incumbent starter Derek Carr, but Cook has impressed his coaches thus far. Today, the NFLPA held its Rookie Premiere event, which featured the top NFL newcomers taking photos and filming videos in their new full uniforms. Cook juggled a couple of footballs in his shoot, where he shows off his new Raiders getup.last_img

Spotted Josh Brolin filming Deadpool 2 in Vancouver PHOTOS

first_imgAdvertisement Josh Brolin was spotted for the first time ever on the set of Deadpool 2. He was in full costume as Cable, the time travelling maniac and comrade of Ryan Reynold’s titular comic book character.He was joined on set by Zazie Beetz, who will be playing Domino in the Vancouver-shot sequel.Deadpool 2 took over Hastings street for most of  holiday Monday, taking advantage of being able to close the streets for the entire day. It will continue to shoot in downtown Vancouver for a few more days as well. Photo by Ken R / Daily Hive Photo by Ken R / Daily Hive Photo by Ken R / Daily Hive Photo by Ken R / Daily Hive Photo by Ken R / Daily Hive Photo by Ken R / Daily Hive Photo by Ken R / Daily Hive Photo by Ken R / Daily Hive Photo by Ken R / Daily Hive Photo by Ken R / Daily Hive Login/Register With: LEAVE A REPLY Cancel replyLog in to leave a comment Photo by Ken R / Daily Hivecenter_img Advertisement Facebook Twitterlast_img read more

Dalpe building off AllRookie campaign

Zac Dalpe was told to report to practice early last week. “I knew something was up, because I don’t usually come in that early,” he said. When Dalpe arrived, he was greeted with the Central Collegiate Hockey Association’s Player of the Month award.Dalpe was honored for the month of January as he led the conference with five goals and three assists.“It’s flattering,” Dalpe said. “It’s a reflection of my team and its play.” The Buckeyes played at an all-conference level throughout January, posting a 4-1-1 record. For Dalpe, the award is just the most recent of many accolades he’s accumulated in his short career as a Buckeye. As a freshman, Dalpe was named to the CCHA All-Rookie Team and was a top-three finalist for Rookie of the Year honors in the conference. His 13 goals ranked seventh in the NCAA for all freshmen and tied him for third on the team. But that wasn’t enough for him. The 6-foot-1-inch forward added 15 pounds to his frame in the offseason. Now in his sophomore campaign, Dalpe leads the team with 15 goals. He has also chipped in 16 assists totaling 31 points, which is also a team high. The assistant captain has played brilliantly all season and is playing his best hockey now as the Buckeyes near the postseason.However, the Buckeyes almost missed out on seeing Dalpe suit up in scarlet and gray. Dalpe, who is a native of Paris, Ontario, had to decide between Ohio State and the Ontario Hockey League.“There was a lot of talk of me going to play in the OHL and I was going to be an older guy [in that league],” Dalpe said. “I didn’t really want to be that. I wanted to be a small fish at first and try and get bigger.” For being a small fish, Dalpe has been a big catch for the Buckeyes.Another factor in Dalpe’s decision to come to Columbus was that he’d be joined by teammates Cory Schneider and Devon Krogh. Dalpe teamed up with the duo in 2007 as a member of the Penticton Vees in British Columbia. “I knew coming in as a freshman I wasn’t going to not know anyone,” Dalpe said. “I was obviously going to have a friend to start out with. That made the transition a little smoother.”Regardless of the reason Dalpe decided to become a Buckeye, the team and fans alike are glad he did and enjoy his ability to light the lamp. But for coach John Markell, Dalpe’s most redeeming quality isn’t his ability to score or to distribute the puck, like he did in a four-assist night Friday. Rather, it’s how hard he works every day in practice.“What I like about him is [that] he and his line mates are [assistant captains] but they’re practicing the way they want to play and it’s making it easier in the games,” Markell said. Dalpe’s effort on the ice – both in practice or during games – sets the tone for the Buckeyes. “He provides us with energy and leadership, even at a young age,” Markell said. “He’s got a lot of passion for the game and that’s what you need at this level.”Growing up in Canada, Dalpe has long since possessed that passion. Dalpe started playing hockey when he was 3 and says he played as much hockey as he could with his brothers Phil and Ben.“We spent a lot of time at the rink growing up, maybe too much for my mom and dad,” Dalpe said. “My brothers have a passion for the game and you can relate to them like no one else through hockey.”It goes without saying that Dalpe’s brothers were ecstatic for him when he was drafted by the Carolina Hurricanes in the 2008 NHL entry draft. Dalpe said getting drafted was a life-long dream come true.“That’s all I wanted growing up. Sharing it with two brothers, who also play hockey, is something special,” Dalpe said. “Obviously to play in the NHL is my dream and I’m still working on it. Hopefully it can come true.” read more

Ohio State running back Jordan Hall out for 10 weeks following foot

Ohio State senior running back Jordan Hall will be out the next 10 weeks following foot surgery this past Friday. According to a statement released by the OSU department of athletics, Hall accidentally suffered a cut to the bottom of his right foot while walking in grass Wednesday. “This is an unfortunate accident to a really fine young man,” OSU coach Urban Meyer said in the release. “He’s handling things well, though. He’ll be in a non-weight bearing cast for about six weeks and then he’ll rehabilitate the injury for at least four weeks after that.” Meyer called Hall his top playmaker after the Buckeyes’ Spring Game on April 21 and is listed as the No. 1 running back on OSU’s first depth chart following spring ball. OSU running backs coach Stan Drayton said Hall made strides in his maturity and growing as a leader during the offseason. “I’ve seen an unbelievable change,” Drayton said. “The leadership and the toughness, both in the weight room and on the field, that was already there, but he’s taken it to another level.” In his career as a Buckeye, Hall has so far totaled 817 rushing yards and five touchdowns in addition to 21 receptions for 202 yards and four touchdowns. read more

Womens Basketball Stephanie Mavunga hopes to cook up victories for Ohio State

Ohio State redshirt senior forward Stephanie Mavunga attempts a shot during the Buckeyes’ 110-80 exhibition win against Ashland on Oct. 29. Credit: Colin Hass-Hill | Sports EditorOhio State redshirt senior guard Linnae Harper was scrolling her Instagram feed during the summer and noticed redshirt senior forward Stephanie Mavunga had posted a picture of herself.But Harper barely even recognized her best friend on the team.“Linnae texted me and was like, ‘Bruh, why do you look so skinny on Instagram?’” Mavunga said Wednesday, “I’m like, ‘I mean, I did lose a few pounds.’ She’s like, ‘Yo, it looks like there’s none of you left.’”Though Mavunga averaged 11.4 points and 10.8 rebounds per game last season, becoming the third Buckeye player to average a double-double in program history, the 6-foot-3 forward decided she needed to slim down, gain muscle and get in better shape.Before this summer, Mavunga’s meals consisted of “whatever’s in the house.”“I would eat pizza, fried chicken, mac and cheese, all that good stuff,” Mavunga said. “So I just eat that stuff and then I’d eat desserts probably every day, or every other day … So I would eat huge, huge meals and then I’d eat late at night, as well. Sweets late at night, all that. It was just terrible.”Little did she know at the time, her laissez-faire approach to her diet was affecting her on-court performance. “Even now, I still practice in a hoodie to sweat more and stuff, that way if you feel all that heavy weight,” Mavunga said. “It’s like, ‘Dang, I don’t even know I played like this last year.’”So after she graduated and began preparation for her final collegiate season, Mavunga put herself on a strict diet.Ohio State redshirt senior forward Stephanie Mavunga answers questions at women’s basketball media day Oct. 10. Credit: Colin Hass-Hill | Sports EditorOut went the red meat, sweets, juice and fried chicken. No longer would she eat three meals with massive portions and snack on foods with empty calories throughout the day.Mavunga replaced the fatty foods and empty carbohydrates with meticulously prepared meals featuring clean meats, fruits and vegetables, as well as her favorite food, salmon. On Tuesday, for example, she ate five times. For breakfast, she had a peanut butter and banana sandwich. She specified she only uses natural peanut butter and eats it on wheat grain toast which, with a smirk, she called “the real stuff.” Then, after practice, she had eggs and turkey. Later that day, she ate a chicken salad before snacking on an apple with peanut butter, one of many dishes she calls her favorite. Mavunga finished the night off with ground chicken, carrots and quinoa.She also trimmed down the size of her meals in favor of a higher quantity of them throughout the day.“So now I eat smaller meals, but I eat so many times a day,” Mavunga said. “I just spread it all out so when I get hungry here, then I’ll eat, then I’ll eat, then I’ll eat. And like I drink a lot of water, so that makes me feel more full.”Mavunga credited her brothers, Julian and Jordache Mavunga, and her sister-in-law, Jeanette Pohlen-Mavunga, for helping her stick to the diet as they all play either professional or college basketball.“We work out every day together,” Mavunga said. “So like I found myself, I’d eat with them before and after my workouts so then at dinner, it’s like why would I just mess up the meal all of a sudden?”A self-described cooking enthusiast, Mavunga makes as many meals as she can at her apartment. Since she lives alone, she said she feels like she does not have anyone around to entice her with less healthy foods, which makes sticking to the diet easier.Mavunga has tried to get some of her teammates into her diet, but has not found much success. Only two players even knew what quinoa was before she told them. Mavunga got Harper to try the stringent, regimented diet, but it didn’t last for more than a week.“Linnae would just start going crazy like, ‘Brah, I just need some juice,’” Mavunga said, laughing. “She’ll text me like, ‘I just want some fried chicken,’ and it would be so funny.”The diet will become more difficult to stick to since the team will travel to away games and she will have to eat meals on the road. But Mavunga is determined to stick to it, even if she allows more cheat days.“She’s gotten in the best shape of her life,” head coach Kevin McGuff said on Friday’s Big Ten coaches teleconference. “She’s really taken her physical stature to another level. I’ve actually never been around a player, in over 20 years coaching, who’s done more in terms of her diet to change her body. She’s really getting up and down the floor and doing a wonderful job right now.”Mavunga said the day after Saturday’s opening exhibition win against Ashland in which she put up 28 points and 23 rebounds, she felt “so much different” than after games in past seasons. She felt better than usual despite playing the majority of the game as the sole post player surrounded by four guards.The Buckeyes need Mavunga to cook defenders on the court just as well as she cooks her salmon as the preseason first-team All-Big Ten forward fulfilling her potential will be key to Ohio State reaching its goal — a Final Four in Columbus. read more

Will Tara Sutarias comments on Kangana Ranaut upset Karan Johar

first_imgWill Tara Sutaria’s praising words for Kangana Ranaut upset Karan Johar?Varinder Chawla/InstagramTara Sutaria, who is all set to make her Bollywood debut in Karan Johar’s Student of the Year 2 (SOTY 2), is in awe of Kangana Ranaut’s success and considers her a role model.Tara reportedly praised Kangana for becoming one of the leading Bollywood actresses without any backup as such. The young actress even confessed that she considers Kangana as her role model.While there is no doubt Kangana rose to fame solely on the basis of her talent, Tara openly praising her at a time when she has been publicly insulting Karan Johar is rather interesting.Kangana and KJo’s rivalry is not a new thing anymore, but lately, the Manikarnika actress has been much vocal on a lot of issues, and in the process had slammed not just Karan but some other industry biggies as well.Kangana had in fact attacked Karan just a month ago while speaking at India Today Conclave. On asked about not being mentioned among the top actresses on Koffee with Karan show, Kangana slammed him saying, “I really feel I stand out. When you talk about actresses, here is a three-time National Awards-winning actress. The Mr Johars of the world try to present a list of people whose acting abilities are questionable. It’s brain-feeding of another magnitude.”She did not stop there and further ridiculed him for allegedly calling her “jobless” on IIFA stage. “Karan mocked me on the IIFA stage and said that I am jobless and I am looking for jobs from him or something like that. I mean, look at my talent and look at your movies. I mean, really? He really called me jobless on some platform? I think some people need a dose of chyavanprash,” she had said at the event.In such a situation, Tara, who is making her debut under Karan’s production house, openly praising Kangana might not be well received by the film-maker.last_img read more